Genistein Aglycone Demonstrates a Protective and Reversible Effect on the Development of Steroid-Induced Secondary Osteoporosis and Increases Bone Breaking Strength in Rats
نویسندگان
چکیده
Alessandra Bitto1, Francesca Polito2, Bruce P Burnett3, Herbert Marini2, Robert Levy3, Domenica Altavilla1 and Francesco Squadrito1 1Department of Clinical and Experimental Medicine and Pharmacology Section of Pharmacology, University of Messina 2Department of Biochemical, Physiological and Nutritional Sciences Section of Physiology and Human Nutrition, University of Messina 3Primus Pharmaceuticals, Inc. Scottsdale, Arizona 1,2Italy 3USA
منابع مشابه
Effects of genistein aglycone in osteoporotic, ovariectomized rats: a comparison with alendronate, raloxifene and oestradiol
BACKGROUND AND PURPOSE Genistein aglycone positively affects bone loss in postmenopausal women, but bone quality data are still lacking. To clarify this, we investigated the effects of genistein compared with alendronate, raloxifene and oestradiol in an animal model of established osteoporosis. EXPERIMENTAL APPROACH Six months after ovariectomy, 96 ovariectomized (OVX) rats were divided into ...
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